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Invitrogen
Phospho-IGF1R beta (Tyr1161) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-37601
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence around phosphorylation site of tyrosine 1161(D-I-Y(p)-E-T)derived from Human IGF-1R.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human breast carcinoma; suggested positive control for ICC/IF is MCF-7 cells.
靶标信息
IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD221; IGF-I receptor; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; line 186
基因别名: A330103N21Rik; CD221; D930020L01; hyft; IGF-1R; Igf1r; IGFIRC; Igfr1; JTK13
UniProt ID: (Rat) P24062, (Mouse) Q60751
Entrez Gene ID: (Rat) 25718, (Mouse) 16001
G-protein alpha-subunit binding
protein tyrosine kinase activity
insulin-like growth factor-activated receptor activity
insulin receptor binding
insulin-like growth factor binding
ATP binding
insulin-like growth factor I binding
identical protein binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin receptor substrate binding
nucleotide binding
protein kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
protein phosphorylation
immune response
axonogenesis
brain development
epidermis development
organ morphogenesis
negative regulation of muscle cell apoptotic process
establishment of cell polarity
male sex determination
positive regulation of cell migration
mammary gland development
exocrine pancreas development
neuron projection development
positive regulation of cytokinesis
response to vitamin E
peptidyl-tyrosine autophosphorylation
negative regulation of apoptotic process
negative regulation of MAPK cascade
positive regulation of MAPK cascade
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of DNA replication
positive regulation of mitotic nuclear division
regulation of JNK cascade
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of DNA metabolic process
protein tetramerization
protein heterooligomerization
inactivation of MAPKK activity
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
prostate gland epithelium morphogenesis
positive regulation of steroid hormone biosynthetic process
transmembrane receptor protein tyrosine kinase signaling pathway
phosphorylation
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