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Invitrogen
Phospho-PIM1 (Tyr309) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-PIM1 (Tyr309) Antibody (PA5-37683) in WB
Western Blot analysis of Phospho-PIM1 (Tyr309) was performed using HUVEC cells treated with PMA. The lane on the right is treated with the antigen-specific peptide. The membrane was probed with Phospho-PIM1 (Tyr309) Polyclonal Antibody (Product # PA5-37683). .
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-37683
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control for Western blot is HUVEC cells.
Target Information
The proto-oncogene PIM1 is upregulated in prostate cancer. PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: non-specific serine/threonine protein kinase; Oncogene PIM1; pim-1 oncogene; pim-1 oncogene (proviral integration site 1); Pim-1L; proto-oncogene serine/threonine-protein kinase Pim-1; proviral integration site 1; unnamed protein product
Gene Aliases: PIM; Pim-1
UniProt ID: (Human) P11309, (Mouse) P06803, (Rat) P26794
Entrez Gene ID: (Human) 5292, (Mouse) 18712, (Rat) 24649
protein phosphorylation
regulation of mitotic cell cycle
positive regulation of G2/M transition of mitotic cell cycle
regulation of transmembrane transporter activity
cellular response to nutrient levels
cellular response to amino acid starvation
defense response to bacterium
negative regulation of apoptotic process
positive regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of innate immune response
positive regulation of transcription, DNA-templated
protein autophosphorylation
protein stabilization
cytolysis in other organism
positive regulation of cardiac muscle cell proliferation
vitamin D receptor signaling pathway
cellular response to interferon-gamma
positive regulation of protein serine/threonine kinase activity
positive regulation of brown fat cell differentiation
non-canonical inflammasome complex assembly
positive regulation of G1/S transition of mitotic cell cycle
regulation of hematopoietic stem cell proliferation
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
positive regulation of cardioblast proliferation
positive regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
cellular detoxification
negative regulation of defense response to bacterium
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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