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Invitrogen
Phospho-ROCK2 (Tyr722) Polyclonal Antibody
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Phospho-ROCK2 (Tyr722) Antibody (PA5-37774) in WB
Western Blot analysis of Phospho-ROCK2 (Tyr722) was performed using extracts from Rat kidney cells. The lane on the left is treated with the antigen-specific peptide. The membrane was probed with Phospho-ROCK2 (Tyr722) Polyclonal Antibody (Product # PA5-37774).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-37774
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence around phosphorylation site of Tyrosine 722 (K-I-Y(p)-E-S) derived from Human ROCK2
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control for Western blot is rat kidney cells.
靶标信息
ROCK2, the predominant ROCK isoform in skeletal muscle, is an important regulator downstream of Rho GTPases. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p150 ROK-alpha; p164 ROCK-2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); RhoA-binding kinase 2; ROCK II; ROCK-II; rockii; ROKalpha
基因别名: B230113H15Rik; mKIAA0619; Rho-kinase; ROCK-II; Rock2; Rock2m; ROK; ROKalpha
UniProt ID: (Rat) Q62868, (Mouse) P70336
Entrez Gene ID: (Rat) 25537, (Mouse) 19878
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
Rho GTPase binding
poly(A) RNA binding
metal ion binding
nucleotide binding
protein kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
neural tube closure
protein phosphorylation
smooth muscle contraction
Rho protein signal transduction
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of centrosome duplication
negative regulation of angiogenesis
actin cytoskeleton organization
chromosome condensation
regulation of actin cytoskeleton organization
regulation of circadian rhythm
regulation of keratinocyte differentiation
rhythmic process
dendrite morphogenesis
centrosome duplication
phosphorylation
intracellular signal transduction
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