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Invitrogen
Phospho-MLK1/MLK2 (Thr312, Thr266) Polyclonal Antibody
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Phospho-MLK1/MLK2 (Thr312, Thr266) Antibody (PA5-37818) in IHC (P)
Immunohistochemical analysis of Phospho-MLK1/MLK2 (Thr312, Thr266) in paraffin-embedded Human brain tissue using Phospho-MLK1/MLK2 (Thr312, Thr266) Polyclonal Antibody (Product # PA5-37818) (left) or the same antibody preincubated with blocking peptide (right).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-37818
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide sequence around phosphorylation site of threonine 312/266(A-G-T(p)-Y-A) derived from Human MLK1/2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control for IHC is human brain tissue.
靶标信息
MLK is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 10; Mitogen-activated protein kinase kinase kinase 9; mixed lineage kinase 2; MKN28 derived nonreceptor_type; MKN28 kinase; serine/threonine kinase
基因别名: BC028668; BC046514; E130314H24Rik; Map3k10; Map3k9; Mlk1; Mlk2; MST; Prke1
UniProt ID: (Mouse) Q66L42, (Mouse) Q3U1V8
Entrez Gene ID: (Mouse) 269881, (Mouse) 338372
nucleotide binding
transcription corepressor activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
bHLH transcription factor binding
protein tyrosine kinase activity
non-receptor serine/threonine protein kinase
protein phosphorylation
smoothened signaling pathway
cell death
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
protein autophosphorylation
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