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Invitrogen
Caspase 1 (Cleaved Asp210) Polyclonal Antibody
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Product Details
PA5-38099
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide derived from human Caspase 1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis (1). The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1/ICE (IL-1b converting enzyme) is similar to the cell death gene CED-3 of Caenorhabditilis elegans and regulates multiple proinflammatory cytokines, including interleukin-1b and interferon-gamma-inducing factor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase-1; cysteine protease; ICE; IL-1 beta converting enzyme; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; interleukin-1 beta converting enzyme; Interleukin-1 beta-converting enzyme; p45; unnamed protein product
Gene Aliases: CASP1; ICE; IL1BC; IL1BCE; P45
UniProt ID: (Human) P29466, (Mouse) P29452
Entrez Gene ID: (Human) 834, (Mouse) 12362
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
peptidase activity
cysteine-type peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
hydrolase activity
enzyme binding
kinase binding
cytokine binding
identical protein binding
CARD domain binding
scaffold protein binding
protease
negative regulation of transcription from RNA polymerase II promoter
plasma membrane repair
pattern recognition receptor signaling pathway
proteolysis
apoptotic process
inflammatory response
signal transduction
osmosensory signaling pathway
protein secretion
protein autoprocessing
protein catabolic process
response to lipopolysaccharide
positive regulation of interleukin-1 beta production
positive regulation of interleukin-18 production
interleukin-18-mediated signaling pathway
defense response to bacterium
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
icosanoid biosynthetic process
ceramide biosynthetic process
regulation of inflammatory response
positive regulation of inflammatory response
protein maturation
defense response to virus
protein poly-ADP-ribosylation
pyroptosis
interleukin-1-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
cellular response to interferon-gamma
cytokine precursor processing
signaling receptor ligand precursor processing
AIM2 inflammasome complex assembly
pyroptotic cell death
positive regulation of tumor necrosis factor-mediated signaling pathway
response to hypoxia
microglial cell activation
myoblast fusion
memory
response to bacterium
regulation of autophagy
response to organic cyclic compound
protein processing
interleukin-1 beta production
response to ATP
response to drug
positive regulation of apoptotic process
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
mitochondrial depolarization
membrane hyperpolarization
cellular response to organic substance
programmed necrotic cell death
toxin transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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