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FIGURE: 1 / 2
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
This antibody is predicted to react with mouse and rat based on sequence homology.
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AKT1 kinase; AKT1m; Akt1m protein; AKT3 kinase; C-AKT; EC 2.7.11.1; murine thymoma viral (v-akt) oncogene homolog 1; PKB alpha; PKB gamma; PKBgamma/Akt3; PKBgamma1; protein kinase Akt-3; protein kinase B alpha; protein kinase B gamma; protein kinase B, gamma; protein kinase B-alpha; proto-oncogene c-AKT; proto-oncogene product; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC-gamma serine/threonine protein kinase; RAC-PK-alpha; RAC-PK-gamma; related to A and C kinases; serine-threonine protein kinase; similar to rat serine-threonine protein kinase; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene 3; tumor rejection antigen peptide pRLib; unnamed protein product; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene-like protein 1
Gene Aliases: AKT; D930002M15Rik; LTR-akt; MPPH; MPPH2; Nmf350; PKB; PKB-ALPHA; PKB-GAMMA; PKB/Akt; PKBalpha; PKBG; PRKBA; PRKBG; RAC; RAC-ALPHA; RAC-gamma; RAC-PK-gamma; STK-2
UniProt ID: (Human) P31749, (Human) Q9Y243, (Rat) P47196, (Mouse) P31750, (Mouse) Q9WUA6, (Rat) Q63484
Entrez Gene ID: (Human) 207, (Human) 10000, (Rat) 24185, (Mouse) 11651, (Mouse) 23797, (Rat) 29414
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