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Phospho-ErbB2 (HER-2) (Tyr1221, Tyr1222) Polyclonal Antibody

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Phospho-ErbB2 (HER-2) (Tyr1221, Tyr1222) Polyclonal Antibody

产品信息

PA5-40205

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化 (IHC)

1:100-1:300
-

免疫细胞化学 (ICC/IF)

5 µg/mL
-

免疫沉淀 (IP)

2-5 µg/mg
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human Neu around the phosphorylation site of Y1221/Y1222.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2609741

产品详细信息

This antibody is predicted to react with mouse and rat based on sequence homology.

靶标信息

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: approximately 68 kDa secreted autoinhibitor glycoprotein; avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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基因别名: c-ERB-2; c-ERB2; c-erbB2; c-neu; CD340; Erbb-2; ERBB2; HER-2; HER-2/neu; HER2; Kiaa3023; mKIAA3023; MLN 19; MLN-19; MLN19; NEU; NGL; p185(erbB2); TKR1; VSCN2

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UniProt ID: (Mouse) P70424

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Entrez Gene ID: (Human) 2064, (Mouse) 13866, (Rat) 24337

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功能
RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity nucleotide binding glycoprotein binding receptor signaling protein tyrosine kinase activity protein C-terminus binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein phosphatase binding ubiquitin protein ligase binding Hsp90 protein binding DNA binding transmembrane signal receptor
参与通路
protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway cell proliferation Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth regulation of microtubule-based process positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated nervous system development peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance positive regulation of cell proliferation glial cell differentiation phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation negative regulation of immature T cell proliferation in thymus myelination positive regulation of GTPase activity estrous cycle positive regulation of transcription from RNA polymerase III promoter positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development response to axon injury oligodendrocyte differentiation liver development central nervous system development skeletal muscle tissue development signal transduction by protein phosphorylation response to progesterone response to drug tongue development regulation of cell differentiation mammary gland involution
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