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Phospho-NMDAR1 (Ser896) Polyclonal Antibody

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Phospho-NMDAR1 (Ser896) Polyclonal Antibody

产品信息

PA5-40256

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化 (IHC)

1:100-1:300
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human NMDAzeta1 around the phosphorylation site of S896.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 0.5% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2608109

产品详细信息

This antibody is predicted to react with mouse and rat based on sequence homology.

靶标信息

NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: GluN1; Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; putative NMDtranscript(altAcc_e2); RP11-350O14.1

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基因别名: DEE101; GluN1; GluRdelta1; Glurz1; GluRzeta1; GRIN1; hNR1; M100174; MRD8; NDHMSD; NDHMSR; NMD-R1; NMDA1; Nmdar; NMDAR1; NR1; Rgsc174

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UniProt ID: (Rat) P35439, (Mouse) P35438

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Entrez Gene ID: (Human) 2902, (Rat) 24408, (Mouse) 14810

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功能
beta-amyloid binding NMDA glutamate receptor activity ion channel activity calcium channel activity calcium ion binding protein binding calmodulin binding ligand-gated ion channel activity ligand-gated sodium channel activity glycine binding glutamate binding transmitter-gated ion channel activity glutamate-gated calcium ion channel activity signaling receptor activity macromolecular complex binding glycine-gated cation channel activity ionotropic glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity cation channel activity enzyme binding voltage-gated cation channel activity glutamate receptor binding neurotransmitter binding protein heterodimerization activity protein dimerization activity receptor activity transmembrane signal receptor
参与通路
ion transport cation transport chemical synaptic transmission brain development visual learning positive regulation of calcium ion transport into cytosol propylene metabolic process calcium-mediated signaling ionotropic glutamate receptor signaling pathway sodium ion transmembrane transport regulation of membrane potential response to ethanol positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity regulation of neuronal synaptic plasticity protein heterotetramerization positive regulation of synaptic transmission, glutamatergic calcium ion homeostasis excitatory postsynaptic potential calcium ion transmembrane transport calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission positive regulation of reactive oxygen species biosynthetic process regulation of cation transmembrane transport cellular response to beta-amyloid response to glycine positive regulation of excitatory postsynaptic potential conditioned taste aversion startle response suckling behavior response to amphetamine calcium ion transport cellular calcium ion homeostasis respiratory gaseous exchange learning or memory learning memory long-term memory associative learning adult locomotory behavior olfactory learning regulation of cell communication positive regulation of cell death response to organic cyclic compound response to amine sensory perception of pain pons maturation cerebral cortex development ion transmembrane transport regulation of ion transmembrane transport social behavior synaptic transmission, glutamatergic positive regulation of apoptotic process response to morphine regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange regulation of long-term neuronal synaptic plasticity rhythmic process regulation of dendrite morphogenesis regulation of axonogenesis neuromuscular process protein tetramerization response to calcium ion regulation of synapse assembly prepulse inhibition male mating behavior response to fungicide cellular response to manganese ion transport
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