Invitrogen

Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody

Name: Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-40301
Availability: InStock

查看其他32个Leptin Receptor抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

Phospho-Leptin Receptor (Tyr1141) Antibody in Western Blot (WB)

图: 1 / 1

Phospho-Leptin Receptor (Tyr1141) Antibody (PA5-40301) in WB

Western Blot analysis of Phospho-Leptin Receptor (Tyr1141) in K562 cells. Samples were incubated with Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody (Product # PA5-40301).

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image Phospho-Leptin Receptor (Tyr1141) Polyclonal Antibody

产品信息

PA5-40301

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

酶联免疫吸附实验 (ELISA)

1:5,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human Ob-R around the phosphorylation site of Y1141.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 0.5% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2608697

产品详细信息

This antibody is predicted to react with mouse based on sequence homology.

靶标信息

The leptin (OB-R) receptor is a member of the cytokine receptor superfamily which plays an important role in mammalian body weight homeostasis and energy balance. Ligand-induced activation of the OB-R by the adipose tissue-secreted hormone, leptin, appears to activate downstream signaling events through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. Leptin can homo-dimerize OB-R extracellular domains while downstream signaling events are initiated upon homo-dimerization of OB-R intracellular domains. Several isoforms of the OB-R which differ in length and signaling capabilities have been reported. RNA transcripts encoding the OB-R long form have been found in the choroid plexus and in the hypothalamus which has been proposed as a control center for satiety and energy expenditure. Mutations in either the mouse OB-R (db) or leptin (ob) genes have been shown to result in early-onset obesity. Metabolic abnormalities attributable to these genotypes include hypercorticoidemia, hyperinsulinemia and insulin resistance, hyperglycemia, altered CNS activity, reduced metabolic rate of brown adipose tissue, and a large increase in white adipose tissue.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: B219; CD antigen CD295; CD295; CD295 antigen; cytokine receptor; HuB219; HuB219.2; LEP-R; Leptin receptor; leptin receptor gene-related protein; OB receptor; OB-R; splice variant form 12.1; Ob receptor; splice variant form 13.2; Ob receptor; splice variant form 6.4; Ob receptor; unnamed protein product

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基因别名: CD295; DB; diabetes; huB219; LEP-R; LEPR; Leprb; LEPRD; LEPROT; Modb1; OB-R; OB-RGRP; obese-like; obl; OBR

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UniProt ID: (Mouse) P48356

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Entrez Gene ID: (Human) 3953, (Mouse) 16847

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