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Invitrogen
Phospho-MLK3 (Ser674) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-40303
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human MLK3 around the phosphorylation site of S674.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with human and rat based on sequence homology.
靶标信息
MAP3K11 (MLK3) is a serine/threonine kinase that activates both the p38 MAP kinase and c-Jun kinase pathways. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: MGC17114; mitogen activated protein kinase kinase kinase 11; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; Src-homology 3 domain-containing proline-rich kinase; unnamed protein product
基因别名: 2610017K16Rik; MAP3K11; MEKK11; MLK-3; MLK3; PTK1; RHOE; SPRK
UniProt ID: (Rat) Q66HA1, (Mouse) Q80XI6
Entrez Gene ID: (Human) 4296, (Rat) 309168, (Mouse) 26403
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
small GTPase binding
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
identical protein binding
protein homodimerization activity
protein serine kinase activity
protein tyrosine kinase activity
Rac GTPase binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
protein phosphorylation
microtubule-based process
JNK cascade
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
cell cycle G1/S phase transition
positive regulation of JNK cascade
activation of MAPK activity
activation of JNKK activity
activation of JUN kinase activity
cell death
cell proliferation
peptidyl-tyrosine phosphorylation
positive regulation of JUN kinase activity
protein autophosphorylation
phosphorylation
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