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Invitrogen
SLC11A1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-42412
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human SLC11A1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA IIMPHNIYLH
Sequence homology: Cow: 86%; Goat: 86%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Rabbit: 93%; Rat: 86%; Sheep: 86%
Target Information
NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Leishmaniasis resistance; Natural resistance-associated macrophage protein 1; NRAMP 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; solute carrier family 11 (sodium/phosphate symporters), member 1; Solute carrier family 11 member 1; unnamed protein product
Gene Aliases: LSH; NRAMP; NRAMP1; SLC11A1
Entrez Gene ID: (Human) 6556
iron ion transmembrane transporter activity
manganese ion transmembrane transporter activity
magnesium ion transmembrane transporter activity
protein homodimerization activity
metal ion transmembrane transporter activity
transition metal ion transmembrane transporter activity
metal ion:proton antiporter activity
zinc:proton antiporter activity
negative regulation of cytokine production
positive regulation of cytokine production
T cell proliferation involved in immune response
neutrophil mediated immunity
positive regulation of dendritic cell antigen processing and presentation
positive regulation of T-helper 1 type immune response
iron ion transport
manganese ion transport
cellular iron ion homeostasis
phagocytosis
inflammatory response
vacuolar acidification
response to bacterium
positive regulation of gene expression
nitrite transport
antimicrobial humoral response
metal ion transport
cellular manganese ion homeostasis
response to lipopolysaccharide
positive regulation of interferon-gamma production
response to interferon-gamma
iron ion transmembrane transport
wound healing
macrophage activation
defense response to bacterium
defense response to protozoan
MHC class II biosynthetic process
cell redox homeostasis
respiratory burst
positive regulation of transcription from RNA polymerase II promoter
antigen processing and presentation of peptide antigen
mRNA stabilization
positive regulation of phagocytosis
defense response to Gram-negative bacterium
multicellular organismal iron ion homeostasis
cadmium ion transmembrane transport
manganese ion transmembrane transport
zinc II ion transmembrane transport
cellular detoxification of cadmium ion
hydrogen ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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