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Invitrogen
TGIF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-48328
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TGIF1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.0 mg/mL
规格
800 µg
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with chicken based on sequence homology.
靶标信息
TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-TG-3'-interacting factor 1; Homeobox protein TGIF1; TALE family homeobox; TG interacting factor 1
基因别名: AA959811; AI462167; TGIF; TGIF1
UniProt ID: (Mouse) P70284
Entrez Gene ID: (Mouse) 21815
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
protein binding
JUN kinase binding
co-SMAD binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
determination of left/right symmetry
negative regulation of cell proliferation
dorsal/ventral pattern formation
regulation of gastrulation
negative regulation of gene expression
nodal signaling pathway
positive regulation of neuron differentiation
positive regulation of fibroblast proliferation
negative regulation of retinoic acid receptor signaling pathway
retina development in camera-type eye
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
