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Invitrogen
TGF beta-3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-49752
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human TGF beta3.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total TGF beta-3 protein.
靶标信息
Transforming growth factor beta 3 (TGF beta 3) is the third member of the transforming growth factor family of cytokines, which also includes TGF beta 1 and beta 2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF beta 3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity.The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF beta cytokines, and indicates an important role in the protection against autoimmunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ16571; H-TGF-b-3; tgf beta 3; TGF-beta-3; Transforming growth factor; transforming growth factor beta-3; Transforming growth factor beta-3 proprotein
基因别名: TGF-B3; Tgfb-3; TGFB3
UniProt ID: (Rat) Q07258
Entrez Gene ID: (Rat) 25717, (Mouse) 21809
type II transforming growth factor beta receptor binding
cytokine activity
transforming growth factor beta receptor binding
growth factor activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
identical protein binding
protein heterodimerization activity
transforming growth factor beta binding
growth factor
activation of MAPK activity
response to hypoxia
in utero embryonic development
transforming growth factor beta receptor signaling pathway
SMAD protein import into nucleus
salivary gland morphogenesis
female pregnancy
aging
negative regulation of DNA replication
negative regulation of cell proliferation
organ morphogenesis
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of macrophage cytokine production
cell growth
lung development
positive regulation of bone mineralization
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of epithelial cell differentiation
mammary gland development
response to progesterone
positive regulation of collagen biosynthetic process
response to laminar fluid shear stress
wound healing
positive regulation of apoptotic process
negative regulation of neuron apoptotic process
response to estrogen
ossification involved in bone remodeling
cell-cell junction organization
regulation of endothelial cell differentiation
positive regulation of DNA replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
cell development
digestive tract development
embryonic neurocranium morphogenesis
inner ear development
regulation of epithelial cell proliferation
positive regulation of protein secretion
positive regulation of filopodium assembly
positive regulation of cell division
palate development
face morphogenesis
frontal suture morphogenesis
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
detection of hypoxia
cellular response to growth factor stimulus
embryo development
growth
regulation of MAPK cascade
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