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Invitrogen
HTR2C Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-49903
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from internal of human 5-HT-2C.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total HTR2C / 5-HT-2C protein.
靶标信息
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT1c receptor; 5-HT2C receptor; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; 5HT2C Receptor; HGNC:5295; RP11-810O3.1; RP23-15B7.1; Serotonin receptor 2C
基因别名: 5-HT2C; 5-HT2cR; 5-HTR2C; 5HT1c; HTR1C; HTR2C; SR1
UniProt ID: (Mouse) P34968
Entrez Gene ID: (Mouse) 15560
behavioral fear response
cGMP biosynthetic process
cellular calcium ion homeostasis
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
behavior
locomotory behavior
feeding behavior
positive regulation of phosphatidylinositol biosynthetic process
positive regulation of gamma-aminobutyric acid secretion
positive regulation of acetylcholine secretion, neurotransmission
phospholipase D-activating G-protein coupled receptor signaling pathway
regulation of neurological system process
regulation of appetite
behavioral response to nicotine
negative regulation of locomotion
response to drug
regulation of corticotropin-releasing hormone secretion
positive regulation of fat cell differentiation
positive regulation of vasoconstriction
negative regulation of dopamine metabolic process
inositol phosphate-mediated signaling
release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of sensory perception of pain
positive regulation of ERK1 and ERK2 cascade
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