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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
The antibody detects endogenous levels of total PTPRN2 protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EC 3.1.3.48; IA-2 beta; IAR; Islet cell autoantigen-related protein; Phogrin; Protein tyrosine phosphatase-NP; PTP IA-2beta; PTP-NP; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2
基因别名: 4930425H11Rik; IA2beta; KIAA0387; mKIAA0387; phogrin; Phol; PTP-NP; PTPRN2
UniProt ID: (Mouse) P80560
Entrez Gene ID: (Mouse) 19276