Invitrogen

PCP4 Polyclonal Antibody

Name: PCP4 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-50188
Availability: InStock

查看其他6个PCP4抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

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PCP4 Antibody (PA5-50188) in WB

Western Blot analysis of PCP4 was performed using Mouse heart tissue lysate. The membrane was probed with PCP4 Polyclonal Antibody (Product # PA5-50188) at dilution 1:500. Secondary antibody: (HRP-conjugated Goat anti rabbit IgG) at 1:5,000 dilution. Exposure time: 5 minutes.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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产品信息

PA5-50188

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Fusion protein corresponding to a region derived from internal residues of human purkinje cell protein 4

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.3 mg/mL

230 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 40% glycerol

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2635641

产品详细信息

The antibody detects endogenous levels of total PCP4 protein.

靶标信息

PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。