Invitrogen

CYFIP2 Polyclonal Antibody

Name: CYFIP2 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-50388
Availability: InStock

查看其他7个CYFIP2抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (2)

CYFIP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 2

CYFIP2 Antibody (PA5-50388) in IHC (P)

Immunohistochemical analysis of CYFIP2 in paraffin embedded Human liver cancer tissue using CYFIP2 Polyclonal Antibody (Product # PA5-50388) at a 1:25 dilution.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image CYFIP2 Polyclonal Antibody

产品信息

PA5-50388

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Fusion protein corresponding to residues near the C terminal of human cytoplasmic FMR1 interacting protein 2

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.2 mg/mL

120 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 40% glycerol

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2635841

产品详细信息

The antibody detects endogenous levels of total CYFIP2 / PIR121 protein.

靶标信息

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。