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Invitrogen
KDM5B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-50693
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 5B
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.7 mg/mL
规格
270 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody detects endogenous levels of total KDM5B protein.
靶标信息
KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(4) demethylase 5B; Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; jumonji, AT rich interactive domain 1B (Rbp2 like); Jumonji/ARID domain-containing protein 1B; Lysine-specific demethylase 5B; PLU-1; putative DNA/chromatin binding motif 1; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1
基因别名: 2010009J12Rik; 2210016I17Rik; AW556288; D1Ertd202e; JARID1B; KDM5B; Kiaa4034; mKIAA4034; PLU-1; PLU1; PUT1; Rb-Bp2; RBBP2H1; RBBP2H1A
UniProt ID: (Mouse) Q80Y84
Entrez Gene ID: (Mouse) 75605
sulfonate dioxygenase activity
DNA binding
transcription corepressor activity
protein binding
zinc ion binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
histone demethylase activity (H3-K4 specific)
histone demethylase activity (H3-trimethyl-K4 specific)
histone demethylase activity (H3-dimethyl-K4 specific)
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
histone modifying enzyme
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
histone H3-K4 demethylation
histone H3-K4 demethylation, trimethyl-H3-K4-specific
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
rhythmic process
oxidation-reduction process
negative regulation of nucleic acid-templated transcription
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