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Invitrogen
ZMIZ1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-50742
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the N terminal of human zinc finger, MIZ-type containing 1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.8 mg/mL
Amount
280 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total ZMIZ1 protein.
Target Information
Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PIAS-like protein Zimp10; retinoic acid induced 17; retinoic acid-induced protein 17; unnamed protein product; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
Gene Aliases: E330020C23; Gm10397; I920194n01; MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10
UniProt ID: (Human) Q9ULJ6, (Mouse) Q6P1E1
Entrez Gene ID: (Human) 57178, (Mouse) 328365
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
protein sumoylation
pyramidal neuron migration
androgen receptor signaling pathway
positive regulation of T cell differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
SMAD protein signal transduction
vasculogenesis
in utero embryonic development
heart morphogenesis
vitellogenesis
positive regulation of fibroblast proliferation
developmental growth
artery morphogenesis
cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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