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Invitrogen
NRG2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-51088
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the Internal region of human Neuregulin-2 (aa 361-410).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Neuregulin-2 Polyclonal Antibody detects endogenous levels of Neuregulin-2 protein.
Target Information
Neuregulin 2 is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: divergent of neuregulin-1; growth factor; neural- and thymus-derived activator for ErbB kinases; pro-NRG2; unnamed protein product
Gene Aliases: DON1; HRG2; NTAK; NTAK alpha1; NTAK alpha2a; NTAK_alpha2a
UniProt ID: (Human) O14511, (Rat) O35569
Entrez Gene ID: (Human) 9542, (Mouse) 100042150, (Rat) 432361
signal transduction
nervous system development
intracellular signal transduction
ERBB4 signaling pathway
animal organ development
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
ERBB2-ERBB3 signaling pathway
ERBB4-ERBB4 signaling pathway
regulation of synapse assembly
regulation of synapse maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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