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Invitrogen
Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) Polyclonal Antibody
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Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) Antibody (PA5-64574) in WB
Western Blot analysis of Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) was performed using Lane 1-6: HeLa, HeLa treated with Calyculin A, HepG2, HepG2 treated with UV, Mouse brain, Rat brain lysates. The membrane was probed with Phospho-DYRK1A/DYRK1B (Tyr321, Tyr273) Polyclonal Antibody (Product # PA5-64574). Secondary antibody: Goat Anti-Rabbit IgG H&L (HRP) at 1:20,000 dilution. Predicted band size: 70 kDa. Obse... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-64574
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DYRK1A/B (Phospho-Tyr321/273)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Phospho-DYRK1A/DYRK1B (Tyr321, 273) Polyclonal Antibody detects endogenous levels of DYRK1A/DYRK1B only when phosphorylated at Tyr321, 273.
靶标信息
DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual Specificity Yak1-related kinase; HP86; Minibrain-related kinase; Mirk protein kinase; MNBH; MP86; Protein kinase minibrain homolog; RP86
基因别名: 2310043O08Rik; D16Ertd272e; D16Ertd493e; DYRK; DYRK1A; DYRK1B; ENSMUSG00000074897; Gm10783; MIRK; mmb; MNB; MNBH; Mp86; PSK47
UniProt ID: (Mouse) Q61214, (Rat) Q63470, (Mouse) Q9Z188
Entrez Gene ID: (Mouse) 13548, (Rat) 25255, (Mouse) 13549, (Rat) 308468
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
identical protein binding
protein self-association
tau protein binding
transcription coactivator activity
regulation of alternative mRNA splicing, via spliceosome
protein phosphorylation
circadian rhythm
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
negative regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
positive regulation of protein deacetylation
myoblast fusion
positive regulation of transcription, DNA-templated
adipose tissue development
nervous system development
regulation of endocytosis
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