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Invitrogen

Phospho-EphB Pan (Tyr600, Tyr602, Tyr614, Tyr596) Polyclonal Antibody

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Phospho-EphB Pan (Tyr600, Tyr602, Tyr614, Tyr596) Polyclonal Antibody

Product Details

PA5-64578

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EPHB1/2/3/4 (Phospho-Tyr600/602/614/596)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2662980

Product Specific Information

Phospho-EphB Pan (Tyr600, Tyr602, Tyr614, Tyr596) Polyclonal Antibody detects endogenous levels of EphB Pan only when phosphorylated at Tyr600, Tyr602, Tyr614, Tyr596.

Target Information

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Developmental kinase 2; Developmental kinase 5; Developmentally-regulated Eph-related tyrosine kinase; EK2; EK5; EK6; ELK; ELK-related protein tyrosine kinase; ELK-related tyrosine kinase; Embryonic kinase 2; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH receptor B4; EPH tyrosine kinase 2; EPH tyrosine kinase 3; EPH-like kinase 2; EPH-like kinase 5; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; ephrin receptor EphB4; Ephrin type-B receptor 1; Ephrin type-B receptor 2; Ephrin type-B receptor 3; Ephrin type-B receptor 4; EphrinB1; EphrinB2; EphrinB3; EphrinB4; HEK-6; Hepatoma transmembrane kinase; human embryo kinase 2; mDK-2; mDK-5; MGC87492; NET; Neural kinase; Neuronally-expressed EPH-related tyrosine kinase; Nuk receptor tyrosine kinase; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; Tyrosine kinase MYK-1; Tyrosine-protein kinase receptor EPH-2; Tyrosine-protein kinase receptor EPH-3; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase TYRO6; unnamed protein product

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Gene Aliases: 9330129L11; AI042935; AW456895; AW488255; BDPLT22; C130099E04Rik; CAPB; Cek10; Cek5; Cek6; CMAVM2; DRT; EK2; EK5; ELK; Elkh; ENSMUSG00000074119; EPHB1; EPHB2; EPHB3; EPHB4; EPHT2; EPHT3; Epth2; EPTH3; ERK; ETECK; ETK2; HEK2; HEK5; HEK6; HFASD; HTK; LMPHM7; MDK2; MDK5; MYK1; NET; Nuk; PCBC; Prkm5; Qek5; RGD1564232; Sek3; Sek4; TYRO11; TYRO5; TYRO6

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UniProt ID: (Human) P54762, (Human) P29323, (Human) P54753, (Human) P54760, (Rat) P09759, (Mouse) Q8CBF3, (Mouse) P54763, (Mouse) P54754, (Mouse) P54761

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Entrez Gene ID: (Human) 2047, (Human) 2048, (Human) 2049, (Human) 2050, (Rat) 24338, (Mouse) 270190, (Mouse) 13844, (Rat) 313633, (Mouse) 13845, (Rat) 287989, (Rat) 686310, (Mouse) 13846

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding axon guidance receptor activity kinase activity transferase activity macromolecular complex binding beta-amyloid binding receptor binding signaling receptor activity identical protein binding protein complex binding transferase activity, transferring phosphorus-containing groups receptor activity molecular_function transmembrane signal receptor
Process(es)
angiogenesis immunological synapse formation cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance skeletal muscle satellite cell activation cell migration cranial nerve development optic nerve morphogenesis hindbrain tangential cell migration central nervous system projection neuron axonogenesis neurogenesis establishment of cell polarity retinal ganglion cell axon guidance cell-substrate adhesion regulation of JNK cascade protein autophosphorylation ephrin receptor signaling pathway camera-type eye morphogenesis system development modulation of synaptic transmission detection of temperature stimulus involved in sensory perception of pain positive regulation of synapse assembly cell chemotaxis dendritic spine development dendritic spine morphogenesis neural precursor cell proliferation regulation of ERK1 and ERK2 cascade negative regulation of skeletal muscle satellite cell proliferation negative regulation of satellite cell differentiation cell morphogenesis urogenital system development positive regulation of immunoglobulin production negative regulation of cell adhesion axonogenesis axonal fasciculation learning or memory learning organ morphogenesis positive regulation of gene expression phosphorylation peptidyl-tyrosine phosphorylation corpus callosum development regulation of blood coagulation positive regulation of cell migration positive regulation of B cell proliferation positive regulation of synaptic plasticity positive regulation of tumor necrosis factor production B cell activation inner ear morphogenesis regulation of JAK-STAT cascade negative regulation of Ras protein signal transduction regulation of neuronal synaptic plasticity positive regulation of long-term neuronal synaptic plasticity regulation of axonogenesis negative regulation of axonogenesis regulation of body fluid levels positive regulation of multicellular organismal process regulation of filopodium assembly regulation of synapse assembly palate development positive regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide commissural neuron axon guidance postsynaptic membrane assembly neuron projection retraction vesicle-mediated intercellular transport tight junction assembly negative regulation of cytokine production involved in inflammatory response positive regulation of long-term synaptic potentiation negative regulation of glutamate receptor signaling pathway positive regulation of glutamate receptor signaling pathway positive regulation of protein localization to plasma membrane cellular response to beta-amyloid neuron projection maintenance positive regulation of protein localization to cell surface regulation of T-helper 17 type immune response regulation of autophagosome assembly regulation of behavioral fear response regulation of cell-cell adhesion substrate adhesion-dependent cell spreading regulation of GTPase activity thymus development digestive tract morphogenesis cell migration involved in sprouting angiogenesis heart morphogenesis regulation of neuron death protein phosphorylation multicellular organism development biological_process signal transduction
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