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Invitrogen
Phospho-SRF (Thr159) Polyclonal Antibody
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Product Details
PA5-64717
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SRF (Phospho-Thr159)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Phospho-SRF (Thr159) Polyclonal Antibody detects endogenous levels of SRF only when phosphorylated at Thr159.
Target Information
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF-binding sites are also constitutive promotor elements in many muscle-specific promotors. SFR is required for cardiac differentiation and maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000039820; Serum response factor; SRF
Gene Aliases: AW049942; AW240594; SRF
UniProt ID: (Mouse) Q9JM73
Entrez Gene ID: (Mouse) 20807
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
serum response element binding
chromatin DNA binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
protein dimerization activity
patterning of blood vessels
in utero embryonic development
mesoderm formation
neuron migration
trophectodermal cell differentiation
heart looping
morphogenesis of an epithelial sheet
cell migration involved in sprouting angiogenesis
leukocyte differentiation
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
actin filament organization
cell-matrix adhesion
multicellular organism development
gastrulation
heart development
long-term memory
negative regulation of cell proliferation
associative learning
response to hormone
epithelial structure maintenance
positive regulation of transcription via serum response element binding
single organismal cell-cell adhesion
hippocampus development
tangential migration from the subventricular zone to the olfactory bulb
actin cytoskeleton organization
contractile actin filament bundle assembly
regulation of cell adhesion
platelet activation
platelet formation
negative regulation of cell migration
neuron projection development
regulation of water loss via skin
response to cytokine
megakaryocyte development
dorsal aorta morphogenesis
mRNA transcription from RNA polymerase II promoter
stress fiber assembly
skin morphogenesis
positive thymic T cell selection
sarcomere organization
positive regulation of cell differentiation
positive regulation of axon extension
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle contraction
positive regulation of transcription by glucose
muscle cell cellular homeostasis
developmental growth
erythrocyte development
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of filopodium assembly
cardiac myofibril assembly
hematopoietic stem cell differentiation
positive regulation of transcription initiation from RNA polymerase II promoter
long term synaptic depression
heart trabecula formation
lung morphogenesis
bronchus cartilage development
trachea cartilage development
cardiac vascular smooth muscle cell differentiation
eyelid development in camera-type eye
lung smooth muscle development
bicellular tight junction assembly
primitive streak formation
epithelial cell-cell adhesion
cellular senescence
negative regulation of beta-amyloid clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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