Invitrogen

GPR37 Polyclonal Antibody

Name: GPR37 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-67865
Availability: InStock

查看其他10个GPR37抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (2)

图: 1 / 2

GPR37 Antibody (PA5-67865) in WB

Western Blot analysis of GPR37 using HuvEc. The membrane was probed with GPR37 Polyclonal Antibody (Product # PA5-67865). The lane on the right is blocked with the antigen-specific peptide.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

Product Image Gallery

Immunogen image

Immunogen Image GPR37 Polyclonal Antibody

产品信息

PA5-67865

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human GPR37.

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2692222

产品详细信息

Predicted to react with Mouse and Rat samples.

靶标信息

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Endothelin B receptor-like protein 1; ETBR-LP-1; G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor 37; G-protein coupled receptor CNS1; Gpcr/cns1; Het-b-r-lp; Pael receptor; PAELR; parkin-associated endothelin B-like receptor; Parkin-associated endothelin receptor-like receptor; probable G-protein coupled receptor 37; Prosaposin receptor GPR37

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基因别名: AI848630; Ednrbl; GPR37; Pael-R

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UniProt ID: (Mouse) Q9QY42, (Rat) Q9QYC6

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Entrez Gene ID: (Mouse) 14763, (Rat) 117549

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功能

signal transducer activity G-protein coupled receptor activity G-protein coupled peptide receptor activity Hsp70 protein binding heat shock protein binding ubiquitin protein ligase binding peptide binding G-protein coupled receptor transmembrane signal receptor

参与通路

signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway locomotion involved in locomotory behavior dopamine biosynthetic process positive regulation of MAPK cascade positive regulation of dopamine metabolic process negative regulation of hydrogen peroxide-induced cell death