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Invitrogen
Nkx6.1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-68213
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human Nkx6.1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with Mouse and Rat samples.
靶标信息
NKX6.1 is a bi-functional transcription factor that has effects in both the central nervous system and in the pancreas. It has both expression and repression effects on genes, leading to the proper formation of motoneurons, oligodendrocytes, and insulin-secreting beta cells. It is known to interact with Pax6 and Pdx-1, probably at or near the 60 amino acid homeobox DNA-binding domain. Due to its obvious relationship to beta cells and CNS, NKX6.1 is becoming a more interesting target for therapies in diabetes and certain brain diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Drosophila NK transcription factor related, gene family 6, locus 1; Homeobox protein NK-6 homolog A; Homeobox protein Nkx-6.1; homeodomain transcription factor Nkx6.1; NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor related locus 1; NK6 transcription factor related, locus 1
基因别名: NKX6-1; Nkx6.1; Nkx61; NKX6A
UniProt ID: (Mouse) Q99MA9, (Rat) O35762
Entrez Gene ID: (Mouse) 18096, (Rat) 65193
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
multicellular organism development
cell proliferation
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
central nervous system neuron differentiation
neurogenesis
cell differentiation
regulation of axon extension
endocrine pancreas development
positive regulation of insulin secretion
positive regulation of neuron differentiation
negative regulation of glial cell differentiation
positive regulation of glial cell differentiation
oligodendrocyte differentiation
regulation of neuron migration
type B pancreatic cell development
response to nicotine
response to drug
cellular response to cytokine stimulus
cellular response to peptide hormone stimulus
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