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Invitrogen
ASXL1 Polyclonal Antibody
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FIGURE: 1 / 1
ASXL1 Antibody (PA5-68360) in IHC (P)
Immunohistochemical analysis of ASXL1 in paraffin-embedded Human esophagus cancer tissue using (left) ASXL1 Polyclonal Antibody (Product # PA5-68360). at a 1:45 dilution and (right) is treated with synthetic peptide. (Original magnification: x200).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-68360
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human ASXL1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.1 mg/mL
Amount
110 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse samples.
Target Information
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Additional sex combs-like protein 1; MGC117280; MGC71111; Polycomb group protein ASXL1; putative Polycomb group protein ASXL1
Gene Aliases: ASXL1; KIAA0978; mKIAA0978
UniProt ID: (Mouse) P59598
Entrez Gene ID: (Mouse) 228790
negative regulation of transcription from RNA polymerase II promoter
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
response to retinoic acid
negative regulation of peroxisome proliferator activated receptor signaling pathway
monoubiquitinated histone H2A deubiquitination
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
negative regulation of retinoic acid receptor signaling pathway
bone development
lung saccule development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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