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Invitrogen
ZIC Pan Polyclonal Antibody
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Product Details
PA5-68610
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N terminal region of human ZIC Pan
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Dog: 100%; Guinea Pig: 86%; Human: 100%; Mouse: 100%; Pig: 92%; Rabbit: 100%; Zebrafish: 79%
Target Information
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heterotaxy 1; transcription factor; unnamed protein product; Zic family member 1 (odd-paired homolog, Drosophila); Zic family member 2 (odd-paired homolog, Drosophila); Zic family member 3 (odd-paired homolog, Drosophila); Zic family member 4; Zic family member 5 (odd-paired homolog, Drosophila); ZIC5; zinc family member 4 protein HZIC4; zinc finger protein 201; zinc finger protein 203; Zinc finger protein of the cerebellum 1; Zinc finger protein of the cerebellum 2; zinc finger protein of the cerebellum 3; zinc finger protein of the cerebellum 4; zinc finger protein of the cerebellum 5
Gene Aliases: BAIDCS; CRS6; HPE5; HTX; HTX1; VACTERLX; ZIC; ZNF201; ZNF203
UniProt ID: (Human) Q15915, (Human) O95409, (Human) O60481, (Human) Q8N9L1, (Human) Q96T25
Entrez Gene ID: (Human) 7545, (Human) 7546, (Human) 7547, (Human) 84107, (Human) 85416
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
promoter-enhancer loop anchoring activity
sequence-specific double-stranded DNA binding
DNA binding
chromatin DNA binding
transcription coactivator activity
sequence-specific DNA binding
promoter-specific chromatin binding
regulation of transcription from RNA polymerase II promoter
central nervous system development
brain development
visual perception
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
skeletal system development
neural plate development
heart looping
atrial cardiac muscle tissue development
smoothened signaling pathway
determination of left/right symmetry
gastrulation
mesoderm development
heart development
embryonic pattern specification
gene expression
stem cell population maintenance
hippocampus development
olfactory bulb development
neuron differentiation
lung development
germ-line stem cell population maintenance
forebrain development
limb morphogenesis
central nervous system segmentation
determination of pancreatic left/right asymmetry
determination of left/right asymmetry in nervous system
outer ear morphogenesis
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
axial mesoderm development
paraxial mesoderm development
stem cell differentiation
face development
left/right pattern formation
left/right axis specification
determination of digestive tract left/right asymmetry
determination of liver left/right asymmetry
primitive streak formation
maintenance of cell number
cranial skeletal system development
pattern specification process
regulation of smoothened signaling pathway
spinal cord development
positive regulation of protein import into nucleus
inner ear morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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