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Invitrogen
SOX17 Polyclonal Antibody
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图: 1 / 4
SOX17 Antibody (PA5-72230) in WB
Western Blot was performed using Anti-SOX17 Polyclonal Antibody (Product # PA5-72230) and a 44 kDa band corresponding to Transcription factor SOX-17 was observed in iPSC differentiated to definitive endoderm and OVCAR-3 when compared to other IMR-32. Nuclear enriched extracts (30 µg lysate) of iPSC (Lane 1), iPSC differentiated to definitive endoderm (Lane 2), OVCAR-3 (Lane 3), IMR-32 (Lane 4) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0301BOX). Resolved proteins were then transferred onto a nitrocellulose mem... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-72230
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 353-387 amino acids from the C-terminal region of mouse Sox17
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
200 µg
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
SOX17 (transcription factor SOX-17) belongs to the SRY-related HMB box family of transcription factors. It acts as a transcription regulator that binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. It promotes degradation of activated CTNNB1. SOX17 plays an essential role in the regulation of embryonic development and is required for normal looping of the embryonic hear tube and for normal development of the definitive gut endoderm. Mutations in the gene can result in vesicoureteral reflux.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: SRY-box containing gene 17; Transcription factor SOX-17
基因别名: Sox-17; SOX17
UniProt ID: (Mouse) Q61473
Entrez Gene ID: (Mouse) 20671
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
beta-catenin binding
transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
HMG box transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
vasculogenesis
endoderm formation
inner cell mass cellular morphogenesis
heart looping
cardiogenic plate morphogenesis
embryonic heart tube morphogenesis
outflow tract morphogenesis
negative regulation of Wnt signaling pathway involved in heart development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
spermatogenesis
gastrulation
endoderm development
endodermal cell fate determination
positive regulation of gene expression
Wnt signaling pathway
rostrocaudal neural tube patterning
signal transduction involved in regulation of gene expression
negative regulation of Wnt signaling pathway
negative regulation of cell growth
protein destabilization
embryonic heart tube development
cell migration involved in gastrulation
regulation of mesodermal cell fate specification
negative regulation of mesodermal cell fate specification
mRNA transcription from RNA polymerase II promoter
regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of protein catabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
embryonic organ development
embryonic foregut morphogenesis
positive regulation of skeletal muscle tissue development
stem cell differentiation
stem cell fate specification
protein stabilization
canonical Wnt signaling pathway
endocardium formation
regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
cardiac cell fate determination
endocardial cell differentiation
common bile duct development
gall bladder development
endodermal digestive tract morphogenesis
renal system development
regulation of stem cell proliferation
negative regulation of canonical Wnt signaling pathway
regulation of stem cell division
regulation of cardiac cell fate specification
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