Search
Invitrogen
PIP5K1C Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-75549
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 346-391 of Human PIP5K1C.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
PIP5K1C lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with -beta-catenin and increases -beta-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance -beta-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitation of RhoA GTPase and integrin activation by chemo attractants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: diphosphoinositide kinase; lipid kinase; phosphatidylinositol 4-phosphate 5-kinase type I gamma; phosphatidylinositol-4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; phosphoinositide 5-kinase; PIP5K1-gamma; PIP5K1gamma; PIP5KI gamma; PIP5KI-gamma; PIP5KIgamma; PIPKIg_v4; ptdIns(4)P-5-kinase 1 gamma; ptdIns(4)P-5-kinase gamma; ptdInsPKIgamma; type I phosphatidylinositol 4-phosphate 5-kinase gamma; type I PIP kinase; unnamed protein product
Gene Aliases: LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5Kgamma; Pip5kIgamma
UniProt ID: (Human) O60331, (Mouse) O70161, (Rat) Q5I6B8
Entrez Gene ID: (Human) 23396, (Mouse) 18717, (Rat) 314641
phosphatidylinositol biosynthetic process
axonogenesis
phosphatidylinositol metabolic process
phosphatidylinositol phosphorylation
platelet aggregation
regulation of postsynaptic neurotransmitter receptor internalization
regulation of synaptic vesicle endocytosis
phagocytosis
synaptic vesicle exocytosis
actin cytoskeleton organization
neutrophil chemotaxis
adherens junction assembly
synaptic vesicle endocytosis
regulation of protein kinase B signaling
membrane organization
clathrin-mediated endocytosis
cell-cell adhesion
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support