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Invitrogen
MLK2 Polyclonal Antibody
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MLK2 Antibody (PA5-75848) in WB
Western blot analysis of MLK2 in Lane 1: HEK293T whole cell lysate, Lane 2: RAW264.7 whole cell lysate, Lane 3: H9C2 whole cell lysate, Lane 4: HeLa whole cell lysate. Samples were incubated with MLK2 polyclonal antibody (Product # PA5-75848) at a dilution of 1:500.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-75848
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human MLK2.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
MAP3K10 (MLK2) is a serine/threonine kinase which has been shown to activate MAPK8/JNK and MKK4/SEK1. This kinase itself can be phoshorylated, and is thus activated by JNK kinases. MAP3K10 functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAP3K9; MEKK9; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; mixed-lineage kinase 2; MKN28 derived nonreceptor_type; MKN28 kinase; MLK1; PRKE1; Protein kinase MST; serine/threonine kinase
基因别名: BC028668; BC046514; MAP3K10; MLK2; MST
UniProt ID: (Rat) D3ZG83, (Mouse) Q66L42
Entrez Gene ID: (Rat) 308463, (Mouse) 269881
transcription corepressor activity
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
ATP binding
bHLH transcription factor binding
nucleotide binding
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
protein phosphorylation
smoothened signaling pathway
cell death
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
phosphorylation
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