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Invitrogen
Cathepsin A (Cleaved Arg326) Polyclonal Antibody
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FIGURE: 1 / 1
Cathepsin A (Cleaved Arg326) Antibody (PA5-76127) in WB
Western blot analysis of Cathepsin A in Lane 1: HCT116 whole cell lysate (40 µg), Lane 2: L02 whole cell lysate (40 µg), Lane 3: HepG2 whole cell lysate (40 µg), Lane 4: AML-12 whole cell lysate (40 µg), Lane 5: PC12 whole cell lysate (40 µg), Lane 6: the Kidney tissue lysate of mouse (40 µg), Lane 7: the Kidney tissue lysate of rat (40 µg). Samples were incubated with Cathepsin A polyclonal antibody (Produ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-76127
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 291-340 of Human Cleaved-Cathepsin A.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Cathepsin A, also known as protective protein/cathepsin A (PPCA), is a lysosomal serine protease encoded by the CTSA gene. It is a member of the alpha/beta hydrolase fold family, sharing structural homology with yeast carboxypeptidase Y. Cathepsin A functions predominantly in protein degradation within acidic endo/lysosomal compartments. It is involved in numerous physiological processes including intracellular protein degradation, energy metabolism, immune responses, and peptide synthesis. Particularly, the cleavage at Arg326 is significant as it pertains to its activation or functional modifications. Cathepsin A operates in conjunction with other enzymes such as neuraminidase and beta-galactosidase in a multi-enzyme complex, which is crucial for the lysosomal degradation pathways. Dysfunctions or mutations in the CTSA gene are associated with galactosialidosis, a lysosomal storage disorder characterized by a deficiency in these enzymatic activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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