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Invitrogen

pan Synuclein Polyclonal Antibody

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说明书
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说明书
Certificates
实验方案
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技术支持
说明书
Certificates
实验方案
问题与答案
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Additional Information:

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产品信息

PA5-78420

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫组化（冰冻） (IHC (F))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-
产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of Rat pan Synuclein. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

规格

20 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol, 1% BSA

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2736318

产品详细信息

Positive Control: mouse brain, rat brain

Predicted Reactivity: Human (93%), Xenopus laevis (84%), Pig (92%), Chicken (87%), Sheep (91%), Chimpanzee (93%), Bovine (91%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha- and beta-synuclein proteins are found primarily in brain tissue, where they are seen mainly in presynaptic terminals. The gamma-synuclein protein is found primarily in the peripheral nervous system and retina, but its expression in breast tumors makes it a candidate as a marker for tumor progression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: 41 synuclein; NACP; non-A beta component of AD amyloid; non-A4 component of amyloid; persyn; phosphoneuroprotein 14; PNP 14; sensory neuron synuclein; synuclein, alpha (non A4 component of amyloid precursor); synuclein, gamma (breast cancer-specific protein 1); unnamed protein product

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基因别名: alpha-Syn; alphaSYN; betaSYN; NACP; persyn

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UniProt ID: (Mouse) O55042, (Rat) P37377, (Mouse) Q91ZZ3, (Rat) Q63754, (Mouse) Q9Z0F7, (Rat) Q63544

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Entrez Gene ID: (Mouse) 20617, (Rat) 29219, (Mouse) 104069, (Rat) 113893, (Mouse) 20618, (Rat) 64347

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功能
SNARE binding magnesium ion binding actin binding enzyme inhibitor activity cysteine-type endopeptidase inhibitor activity copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding enzyme activator activity ferrous iron binding zinc ion binding lipid binding tubulin binding oxidoreductase activity kinesin binding enzyme binding protein domain specific binding Hsp70 protein binding histone binding identical protein binding alpha-tubulin binding phospholipase binding tau protein binding beta-tubulin binding arachidonic acid binding phosphoprotein binding binding, bridging dynein complex binding protein sequestering activity transporter regulator activity cuprous ion binding fatty acid binding phospholipase D inhibitor activity transition metal ion binding
参与通路
chemical synaptic transmission adult locomotory behavior protein secretion regulation of dopamine secretion regulation of neurotransmitter secretion synaptic vesicle endocytosis synapse organization regulation of cellular response to stress dopamine metabolic process negative regulation of neuron apoptotic process microglial cell activation positive regulation of receptor recycling positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process glutathione metabolic process mitochondrial membrane organization response to xenobiotic stimulus response to iron(II) ion negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion synaptic vesicle exocytosis synaptic vesicle priming negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion response to lipopolysaccharide response to interferon-gamma cellular response to oxidative stress SNARE complex assembly positive regulation of SNARE complex assembly regulation of locomotion dopamine biosynthetic process mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation negative regulation of apoptotic process positive regulation of endocytosis negative regulation of exocytosis positive regulation of exocytosis negative regulation of dopamine metabolic process behavioral response to cocaine regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity synaptic vesicle transport positive regulation of inflammatory response positive regulation of synaptic transmission regulation of acyl-CoA biosynthetic process protein oligomerization protein tetramerization positive regulation of release of sequestered calcium ion into cytosol negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake regulation of norepinephrine uptake negative regulation of norepinephrine uptake excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin receptor signaling pathway regulation of microtubule cytoskeleton organization response to interleukin-1 cellular response to copper ion positive regulation of hydrogen peroxide catabolic process positive regulation of protein localization to cell periphery negative regulation of chaperone-mediated autophagy regulation of presynapse assembly amyloid fibril formation regulation of reactive oxygen species metabolic process aggressive behavior peripheral nervous system development response to cocaine cellular response to hydrostatic pressure response to desipramine cellular response to fibroblast growth factor stimulus calcium ion homeostasis
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