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Invitrogen
AKR1C1/AKR1C2 Polyclonal Antibody
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AKR1C1/AKR1C2 Antibody (PA5-78752) in ICC/IF
Immunocytochemistry analysis of AKR1C1/C2 using anti-AKR1C1/C2 antibody (Product # PA5-78752). AKR1C1/C2 was detected in an immunocytochemical section of HepG2 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 5 μg/mL rabbit anti-AKR1C1/C2 antibody (Product # PA5-78752) overnight at 4°C. Dy... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78752
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human AKR1C1/C2 recombinant protein (Position: M1-K123).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human A549 whole cell, human HCCP tissue, rat liver tissue, rat kidney tissue, mosue liver tissue, mosue kidney tissue. ICC/IF: HepG2 cell. Flow: HepG2 cell.
靶标信息
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. And this gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); 20-alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-HSD3; 3-alpha-hydroxysteroid dehydrogenase; 3beta-hydroxysteroid 3-dehydrogenase; Aldo-keto reductase family 1 member C1; Aldo-keto reductase family 1 member C2; Aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); aldo-keto reductase family 1, member C21; aldo-keto reductase family 1, member C6; Chlordecone reductase homolog HAKRC; Chlordecone reductase homolog HAKRD; DD-2; DD/BABP; DD1; Dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 2; Dihydrodiol dehydrogenase/bile acid-binding protein; HBAB; High-affinity hepatic bile acid-binding protein; type 5 17beta-hydroxysteroid dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase
基因别名: AKR1C1; AKR1C2; Akr1c21; Akr1c6; DDH; DDH1; DDH2; Hsd17b5
UniProt ID: (Rat) Q6AYQ2
Entrez Gene ID: (Rat) 307092, (Rat) 291283
retinal dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
alditol:NADP+ 1-oxidoreductase activity
oxidoreductase activity
phenanthrene 9,10-monooxygenase activity
carboxylic acid binding
bile acid binding
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
oxidoreductase
reductase
metabolite interconversion enzyme
response to drug
response to estrogen
daunorubicin metabolic process
doxorubicin metabolic process
oxidation-reduction process
cellular response to jasmonic acid stimulus
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
digestion
steroid metabolic process
positive regulation of cell proliferation
epithelial cell differentiation
progesterone metabolic process
positive regulation of protein kinase B signaling
cellular response to prostaglandin D stimulus
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