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Invitrogen
CD68 Polyclonal Antibody
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CD68 Antibody (PA5-78996) in IHC (P)
Immunohistochemistry (Paraffin) analysis of CD68 in paraffin-embedded section of mouse spleen tissue using CD68 Polyclonal Antibody (Product # PA5-78996). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 5 µg/mL dilution overnight at 4°C. ... View More
产品信息
PA5-78996
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
C. elegans,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of mouse CD68 (312-326aa AFCITRRRQSTYQPL).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat spleen tissue, mouse spleen tissue, mouse RAW2647 whole cell. IHC: mouse liver tissue, mouse spleen tissue, rat spleen tissue, rat lung tissue, rat lung tissue, rat liver tissue. Flow: RAW2647 cell.
靶标信息
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD68; CD68 antigen; Macrosialin
基因别名: Cd68; gp110; Lamp4; Scard1
UniProt ID: (Mouse) P31996
Entrez Gene ID: (Mouse) 12514, (Rat) 287435
