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Invitrogen
CNTF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79056
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived rat CNTF recombinant protein (Position: A2-M200).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat PC-12 whole cell, rat NRK whole cell, rat RH-35 whole cell, rat brain tissue, rat liver tissue, rat spleen tissue, rat testis tissue. IHC: mouse brain tissue, rat brain tissue.
靶标信息
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ciliary neurotrophic factor; ciliary neurotropic factor; CNTF; H-CNTF
基因别名: AI429687; Cntf
UniProt ID: (Mouse) P51642, (Rat) P20294
Entrez Gene ID: (Mouse) 12803, (Rat) 25707
JAK-STAT cascade
multicellular organism development
nervous system development
positive regulation of cell proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
cell differentiation
positive regulation of cell growth
growth
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of JAK-STAT cascade
negative regulation of photoreceptor cell differentiation
regulation of retinal cell programmed cell death
positive regulation of hormone secretion
astrocyte activation
muscle organ morphogenesis
neuron development
positive regulation of axon regeneration
protein heterooligomerization
regulation of resting membrane potential
membrane hyperpolarization
ciliary neurotrophic factor-mediated signaling pathway
negative regulation of neuron death
response to light intensity
response to electrical stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
