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Invitrogen
JAB1 Polyclonal Antibody
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JAB1 Antibody (PA5-79060) in ICC/IF
Immunocytochemistry analysis of JAB1 using anti-JAB1 antibody (Product # PA5-79060). JAB1 was detected in a section of A431 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 1μg/mL rabbit anti-JAB1 antibody (Product # PA5-79060) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The section was developed using Strepavidin-Biotin-Complex (SABC) with DAB a... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79060
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human JAB1 recombinant protein (Position: M8-S334).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Raji whole cell, human K562 whole cell, human PC-3 whole cell, human Hela whole cell, human A549 whole cell, human HEK293 whole cell, rat brain tissue, rat heart tissue, mouse brain tissue, mouse heart tissue, mouse SP2/0 whole cell. IHC: mouse testis tissue, rat testis tissue, human mammary cancer tissue. ICC/IF: A431 cell. Flow: U20S cell, U937 cell.
靶标信息
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: COP9 (constitutive photomorphogenic) homolog, subunit 5; COP9 complex S5; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; Jun activation domain-binding protein 1; Jun coactivator; Kip1 C-terminus-interacting protein 2; MGC3149; SGN5
基因别名: AI303502; COPS5; CSN5; JAB1; Kic2; Mov34; Sgn5
UniProt ID: (Mouse) O35864
Entrez Gene ID: (Rat) 312916, (Mouse) 26754
protein deneddylation
proteolysis
cullin deneddylation
protein deubiquitination
positive regulation of transcription from RNA polymerase II promoter
regulation of JNK cascade
regulation of cell cycle
exosomal secretion
regulation of transcription, DNA-templated
regulation of IRE1-mediated unfolded protein response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
