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Invitrogen
Alpha A Crystallin Polyclonal Antibody
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图: 1 / 5
Alpha A Crystallin Antibody (PA5-79074) in IHC (P)
Immunohistochemistry analysis of Alpha A Crystallin on paraffin-embedded mouse spleen tissue. Sample was incubated with Alpha A Crystallin polyclonal antibody (Product# PA5-79074) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) with DAB chromogen method.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79074
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human Alpha A Crystallin recombinant protein (Position: M1-S173).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat spleen tissue, mouse eye ball tissue, SMMC-7721 whole cell. IHC: mouse spleen tissue, rat spleen tissue. Flow: HepG2 cell.
靶标信息
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens. The mammalian lens contains 3 major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products-alpha-A and alpha-B. There are at least 5 different proteins comprising the beta-crystallins. The gamma-crystallins are monomeric, but there are at least 5 gamma crystallins identified in bovine and rat lens. Alpha-Crystallin comprises 40% of total lens protein composition. In addition to maintaining proper refractive index, it also functions in a chaperone like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of the alpha-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acry 1; Alpha-crystallin A chain; CRYA 1; Crystallin Alpha 1; crystallin, alpha 1; Crystallin, alpha polypeptide A; Heat shock protein beta-4; Heat shock protein family B member 4; HSPB 4; HspB4; lens opacity 18
基因别名: Acry-1; Crya-1; CRYA1; CRYAA; DAcry-1; HSPB4; lop18
UniProt ID: (Rat) P24623, (Mouse) P24622
Entrez Gene ID: (Rat) 24273, (Mouse) 12954
response to hypoxia
positive regulation of protein phosphorylation
lens development in camera-type eye
lens morphogenesis in camera-type eye
protein folding
apoptotic process
mitochondrion organization
actin filament organization
microtubule-based process
tubulin complex assembly
visual perception
response to lead ion
negative regulation of gene expression
positive regulation of cell growth
negative regulation of intracellular transport
response to drug
response to hydrogen peroxide
camera-type eye development
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
embryonic camera-type eye morphogenesis
protein homooligomerization
response to glucocorticoid
apoptotic process involved in morphogenesis
response to UV-A
lens fiber cell morphogenesis
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