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Invitrogen
Cullin 5 Polyclonal Antibody
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图: 1 / 2
Cullin 5 Antibody (PA5-79100) in WB
Western blot analysis of Cullin 5 in Lane 1: rat brain tissue lysate, Lane 2: rat spleen tissue lysate, Lane 3: rat heart tissue lysate, Lane 4: rat kidney tissue lysate, Lane 5: mouse brain tissue lysate, Lane 6: mouse spleen tissue lysate, Lane 7: mouse heart tissue lysate, Lane 8: mouse kidney tissue lysate, Lane 9: mouse testis tissue lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellu... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79100
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived human Cullin 5 recombinant protein (Position: A2-D105).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat brain tissue, rat spleen tissue, rat heart tissue, rat kidney tissue, mouse brain tissue, mouse spleen tissue, mouse heart tissue, mouse kidney tissue, mouse testis tissue.
靶标信息
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CUL-5; Cullin-5; VACM-1; Vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein
基因别名: 4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; CUL5; VACM-1; VACM1
UniProt ID: (Rat) Q9JJ31, (Mouse) Q9D5V5
Entrez Gene ID: (Rat) 64624, (Mouse) 75717
protein polyubiquitination
ubiquitin-dependent protein catabolic process
response to osmotic stress
G-protein coupled receptor signaling pathway
protein ubiquitination
cerebral cortex radially oriented cell migration
radial glia guided migration of Purkinje cell
regulation of cytosolic calcium ion concentration
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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