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Invitrogen
CD105 (Endoglin) Polyclonal Antibody
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CD105 (Endoglin) Antibody (PA5-79203) in IHC (P)
Immunohistochemistry analysis of CD105 (Endoglin) on paraffin-embedded mouse spleen tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with CD105 (Endoglin) polyclonal antibody (Product# PA5-79203) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 min... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79203
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse CD105 recombinant protein (Position: E27-L226).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse lung tissue. IHC: mouse kidney tissue, mouse liver tissue, mouse spleen tissue, rat kidney tissue, rat liver tissue, rat spleen tissue.
靶标信息
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD105; Cell surface MJ7/18 antigen; Endoglin; ORW; transmembrane glycoprotein
基因别名: AI528660; AI662476; CD105; Edg; Endo; Eng; S-endoglin
UniProt ID: (Mouse) Q63961
Entrez Gene ID: (Mouse) 13805, (Rat) 497010
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
BMP binding
protein homodimerization activity
transforming growth factor beta binding
transmembrane signal receptor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
vasculogenesis
response to hypoxia
positive regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
heart looping
positive regulation of systemic arterial blood pressure
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
protein phosphorylation
cell adhesion
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
cell migration
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
extracellular matrix disassembly
negative regulation of cell migration
positive regulation of BMP signaling pathway
negative regulation of protein autophosphorylation
positive regulation of collagen biosynthetic process
intracellular signal transduction
wound healing
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
cell motility
negative regulation of nitric-oxide synthase activity
cell chemotaxis
negative regulation of pathway-restricted SMAD protein phosphorylation
extracellular matrix constituent secretion
detection of hypoxia
chronological cell aging
response to corticosteroid
response to statin
bone development
cellular response to mechanical stimulus
response to transforming growth factor beta
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