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Invitrogen
HOXA11 Polyclonal Antibody
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FIGURE: 1 / 3
HOXA11 Antibody (PA5-79387) in WB
Western blot analysis of HOXA11 in Lane 1: rat brain tissue lysate, Lane 2: human placenta tissue lysate, Lane 3: HLEA whole cell lysate, Lane 4: HT1080 whole cell lysate, Lane 5: HEPA whole cell lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked with 5% Non-fat Milk/TBS for 1.5 hours at room temperature, incubated with HOXA11 po... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79387
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human HOXA11 recombinant protein (Position: H74-R245).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Brain Tissue, Human Placenta Tissue, HLEA whole cell, HT1080 whole cell, HEPA whole cell. Flow: U937 cell.
Target Information
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box A11; homeobox A11; Homeobox protein Hox-1.9; Homeobox protein Hox-1I; Homeobox protein Hox-A11; HOX11
Gene Aliases: Hox-1.9; HOX1I; Hoxa-11; HOXA11
UniProt ID: (Mouse) P31311
Entrez Gene ID: (Mouse) 15396, (Rat) 103692131
skeletal system development
metanephros development
branching involved in ureteric bud morphogenesis
organ induction
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
spermatogenesis
single fertilization
mesodermal cell fate specification
male gonad development
anterior/posterior pattern specification
dorsal/ventral pattern formation
proximal/distal pattern formation
regulation of gene expression
positive regulation of cell development
embryonic limb morphogenesis
regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
embryonic digit morphogenesis
positive regulation of transcription, DNA-templated
developmental growth
uterus development
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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