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Invitrogen
HSD17B4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79405
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Hydroxysteroid (17-beta) Dehydrogenase 4 (744-761aa NIMLSQKLQMILKDYAKL).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human RT4 whole cell, rat liver tissue, rat testis tissue, mouse liver tissue. IHC: Human Lung Cancer tissue, Human Intestinal Cancer tissue.
靶标信息
Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; MFP-2; Multifunctional protein 2; Peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type II; Short chain dehydrogenase/reductase family 8C member 1
基因别名: 17-beta-HSD; 17[b]-HSD; DBP; 4; EDH17B4; HSD17B4; MFE-2; Mfp-2; MFP2; MPF-2; perMFE-2; SDR8C1
UniProt ID: (Mouse) P51660, (Rat) P97852
Entrez Gene ID: (Mouse) 15488, (Rat) 79244
3-hydroxyacyl-CoA dehydrogenase activity
receptor binding
oxidoreductase activity
long-chain-enoyl-CoA hydratase activity
lyase activity
isomerase activity
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
protein homodimerization activity
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
testosterone dehydrogenase [NAD(P)] activity
very long-chain fatty acid metabolic process
osteoblast differentiation
lipid metabolic process
fatty acid metabolic process
fatty acid beta-oxidation
metabolic process
androgen metabolic process
estrogen metabolic process
very long-chain fatty-acyl-CoA metabolic process
medium-chain fatty-acyl-CoA metabolic process
oxidation-reduction process
Sertoli cell development
cholesterol metabolic process
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