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Invitrogen
IL23R Polyclonal Antibody
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IL23R Antibody (PA5-79490) in WB
Western blot analysis of IL23 Receptor in, Lane 1: mouse brain tissue lysates, Lane 2: mouse liver tissue lysates, Lane 3: mouse kidney tissue lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. The membrane was blocked with 5% Non-fat Milk/ TBS for 1. 5 hour at RT. The membrane w... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79490
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse IL23 Receptor recombinant protein (Position: I25-D233).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse brain tissue, mouse liver tissue, mouse kidney tissue.
靶标信息
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IBD17; IL 23R; IL-23 receptor; interleukin 23 receptor; interleukin 23 receptor-like; Interleukin-23 receptor
基因别名: IL-23R; Il23r
UniProt ID: (Mouse) Q8K4B4
Entrez Gene ID: (Rat) 689932, (Mouse) 209590
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
biological_process
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
response to interferon-gamma
interleukin-23-mediated signaling pathway
immune system process
leukocyte mediated immunity
inflammatory response
JAK-STAT cascade
cytokine-mediated signaling pathway
innate immune response
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
