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Invitrogen
MEKK1 Polyclonal Antibody
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FIGURE: 1 / 2
MEKK1 Antibody (PA5-79629) in WB, IHC (F)
Hepatology communications 2022 -
FIG. 7 Integration among the gut microbiome, portal serum metabolome, and liver transcriptome. Female and male WT mice were fed the control or ethanol LDC diets for 6 weeks (peak injury). To achieve resolution from ALD mice were switched to control diet for 3 or 14 days (early or late resolution, respectively). Spearman's rank correlation plot depicting the correlation between metabolites and bacteria in fe... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79629
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK1 (1418-1432aa PEVLRGQQYGRSCDV).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: MCF-7 whole cell. IHC: Human Intestinal Cancer Tissue.
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; protein kinase MEKK1
Gene Aliases: MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6
UniProt ID: (Human) Q13233, (Rat) Q62925
Entrez Gene ID: (Human) 4214, (Mouse) 26401, (Rat) 116667
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
zinc ion binding
protein kinase binding
ubiquitin protein ligase activity
protein serine kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase activity
ubiquitin-protein transferase activity
cytoskeletal protein binding
JUN kinase binding
mitogen-activated protein kinase kinase binding
macromolecular complex binding
sphingolipid binding
mitogen-activated protein kinase binding
MAPK cascade
protein phosphorylation
cell surface receptor signaling pathway
Fc-epsilon receptor signaling pathway
cellular response to mechanical stimulus
protein polyubiquitination
morphogenesis of an epithelial sheet
epithelial cell morphogenesis
ubiquitin-dependent protein catabolic process
transforming growth factor beta receptor signaling pathway
JNK cascade
apoptotic mitochondrial changes
peptidyl-serine phosphorylation
regulation of cell migration
positive regulation of actin filament polymerization
negative regulation of actin filament bundle assembly
wound healing
camera-type eye development
positive regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of JUN kinase activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
protein autophosphorylation
positive regulation of viral transcription
eyelid development in camera-type eye
positive regulation of canonical Wnt signaling pathway
regulation of actin filament organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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