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Invitrogen
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human HepG2 whole cell, human A549 whole cell, human PANC-1 whole cell, human SGC-7901 whole cell, human MDA-MB-231 whole cell, rat spleen tissue, rat lung tissue, rat kidney tissue, mouse spleen tissue, mouse lung tissue, mouse kidney tissue. IHC: human intestinal cancer tissue, mouse small intestine tissue, rat small intestine tissue, human lung cancer tissue. ICC/IF: A431 cell. Flow: Hela cell, U-87 cell.
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; VAULT1; vRNP
基因别名: 2310009M24Rik; LRP; MVP; VAULT1
UniProt ID: (Rat) Q62667, (Mouse) Q9EQK5
Entrez Gene ID: (Rat) 64681, (Mouse) 78388