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Invitrogen
NOD1 Polyclonal Antibody
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图: 1 / 6
NOD1 Antibody (PA5-79747) in ICC/IF
Immunocytochemistry analysis of NOD1 on SMMC-7721 cells. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with NOD1 polyclonal antibody (Product# PA5-79747) with a dilution of 1 µg/mL (overnight at 4°C). Development was performed using Streptavidin-Biotin-Complex (SABC) with DAB chromogen method.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79747
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human CARD4 recombinant protein (Position: M1-M160).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: A549 whole cell, Rat Cardiac Muscle Tissue. IHC: Human Placenta tissue. ICC/IF: A549 Cell, Hela Cell, SMMC-7721 Cell.
靶标信息
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Caspase recruitment domain-containing protein 4; hNod1; Nucleotide-binding oligomerization domain-containing protein 1
基因别名: CARD4; NOD1; RGD1562269
Entrez Gene ID: (Rat) 500133
positive regulation of dendritic cell antigen processing and presentation
activation of cysteine-type endopeptidase activity involved in apoptotic process
detection of bacterium
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of stress-activated MAPK cascade
intracellular signal transduction
interleukin-8 biosynthetic process
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of JNK cascade
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of ERK1 and ERK2 cascade
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