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Invitrogen
PF4 Polyclonal Antibody
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PF4 Antibody (PA5-79810) in IHC (P)
Immunohistochemistry analysis of PF4 on paraffin-embedded mouse spleen tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with PF4 polyclonal antibody (Product# PA5-79810) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Development... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79810
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived rat PF4 recombinant protein (Position: V30-S105).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat spleen tissue. IHC: mouse spleen tissue, rat spleen tissue.
靶标信息
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; PF-4; Platelet factor 4
基因别名: Cxcl4; PF-4; Pf4; Pf4a; RATPF4A; Scyb4
UniProt ID: (Rat) P06765, (Mouse) Q9Z126
Entrez Gene ID: (Rat) 360918, (Mouse) 56744
positive regulation of leukocyte chemotaxis
protein complex assembly
inflammatory response
immune response
G-protein coupled receptor signaling pathway
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
negative regulation of angiogenesis
cytokine-mediated signaling pathway
platelet activation
leukocyte chemotaxis
positive regulation of cAMP metabolic process
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
regulation of cell proliferation
positive regulation of cAMP-mediated signaling
negative regulation of MHC class II biosynthetic process
positive regulation of macrophage differentiation
negative regulation of megakaryocyte differentiation
negative regulation of cytolysis
positive regulation of transcription from RNA polymerase II promoter
chemokine-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
chemotaxis
cell chemotaxis
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