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Invitrogen
Nhe-1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-80033
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human SLC9A1 recombinant protein (Position: H543-Q815).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat PC-12 whole cell, human MCF-7 whole cell. IHC: rat kidney tissue, human mammary cancer tissue, mouse kidney tissue.
靶标信息
The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APNH; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; NHE-1; slow-wave epilepsy; Sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; Solute carrier family 9 member 1; solute carrier family 9, member 1
基因别名: Apnh; APNH1; AW554487; mir-5122; Mir5122; NHE1; SLC9A1; swe
UniProt ID: (Rat) P26431, (Mouse) Q61165
Entrez Gene ID: (Rat) 24782, (Mouse) 20544
regulation of the force of heart contraction
sodium ion transport
cellular sodium ion homeostasis
regulation of pH
response to acidic pH
positive regulation of cardiac muscle hypertrophy
regulation of cardiac muscle contraction by calcium ion signaling
response to organic cyclic compound
cell growth
cell differentiation
positive regulation of cell growth
cellular response to insulin stimulus
sodium ion transmembrane transport
positive regulation of mitochondrial membrane permeability
response to muscle stretch
response to drug
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of action potential
positive regulation of transcription from RNA polymerase II promoter
regulation of intracellular pH
positive regulation of NFAT protein import into nucleus
regulation of sensory perception of pain
cardiac muscle cell differentiation
positive regulation of calcineurin-NFAT signaling cascade
neuron death
cellular response to antibiotic
cellular response to electrical stimulus
cellular response to organic cyclic compound
sodium ion export
cellular response to hypoxia
cellular response to acidic pH
cellular response to epinephrine stimulus
cardiac muscle cell contraction
regulation of the force of heart contraction by cardiac conduction
sodium ion import across plasma membrane
positive regulation of the force of heart contraction
positive regulation of intracellular signal transduction
hydrogen ion transmembrane transport
positive regulation of calcium:sodium antiporter activity
transport
ion transport
cation transport
embryo development
transmembrane transport
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