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Invitrogen
TFF2 Polyclonal Antibody
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TFF2 Antibody (PA5-80111) in IHC (P)
Immunohistochemistry analysis of TFF2 on paraffin-embedded mouse gastric tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with TFF2 polyclonal antibody (Product# PA5-80111) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Developm... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-80111
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived mouse TFF2 recombinant protein (Position: E24-Y129).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: mouse testis tissue. IHC: mouse gaster tissue, rat gaster tissue.
靶标信息
Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing and protection of the gastrointestinal epithelia. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. SP (spasmolytic polypeptide), also designated Trefoil factor 2 (TFF2) precursor, is a trefoil protein that functions to inhibit gastrointestinal motility and gastric acid secretion. SP may also act as a structural component of the gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. A downregulation of SP expression is associated with primary gastric cancer, and a progressive loss of this protein is likely to be involved in the early stage of the multi-step gastric carcinogenesis pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: SP; Spasmolytic polypeptide; Trefoil factor 2; trefoil factor 2 (spasmolytic protein 1)
基因别名: mSP; Sml1; SP; Tff2
UniProt ID: (Rat) Q09030
Entrez Gene ID: (Rat) 116592, (Mouse) 21785
positive regulation of cell proliferation
calcium-mediated signaling
regulation of cell migration
negative regulation of macrophage activation
negative regulation of inflammatory response
negative regulation of gastric acid secretion
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
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