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Invitrogen
Thrombopoietin Polyclonal Antibody
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图: 1 / 1
Thrombopoietin Antibody (PA5-80126) in WB
Western blot analysis of TPO in Lane 1: rat liver tissue lysate, Lane 2: rat spleen tissue lysate, Lane 3: rat brain tissue lysate, Lane 4: rat kidney tissue lysate, Lane 5: rat thymus tissue lysate, Lane 6: rat PC-12 cell lysate, Lane 7: rat RH35 cell lysate, Lane 8: mouse SP20 cell lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blo... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-80126
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived rat Thrombopoietin recombinant protein (Position: A27-H259).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat liver tissue, rat spleen tissue, rat brain tissue, rat kidney tissue, rat thymus tissue, rat PC-12 cell, rat RH35 cell, mouse SP20 cell.
靶标信息
Thrombopoietin (TPO, THPO, MPL ligand, megakaryocyte colony-stimulating factor) is responsible for the generation of platelets through its action on hematopoietic cells committed to the megakaryocyte lineage. Binding of thrombopoietin to its receptor, MPL (CD110), initiates a signaling cascade via JAK/STAT, MAPK, and PI3K/AKT signaling pathways that leads to the proliferation and differentiation of megakaryocytes and, ultimately, to the production of platelets (thrombopoiesis). Thrombopoietin is constitutively produced by the liver and has a predicted molecular weight of 38 kDa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; ML; Myeloproliferative leukemia virus oncogene ligand; Thrombopoietin
基因别名: Mgdf; Ml; Mpllg; Thpo; Tpo
UniProt ID: (Rat) P49745, (Mouse) P40226
Entrez Gene ID: (Rat) 81811, (Mouse) 21832
positive regulation of protein phosphorylation
cell proliferation
positive regulation of cell proliferation
myeloid cell differentiation
response to lipopolysaccharide
thrombopoietin-mediated signaling pathway
positive regulation of megakaryocyte differentiation
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
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