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Invitrogen
p73 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-80175
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human p73 recombinant protein (Position: M1-E198).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA whole cell, MCF-7 whole cell, COLO320 whole cell. IHC: Human Intestinal Cancer Tissue, Rat Brain Tissue, Mouse Intestine Tissue.
靶标信息
P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; transformation related protein 73; Tumor protein p73
基因别名: deltaNp73; P73; TAp73; TP73; Trp73
UniProt ID: (Mouse) Q9JJP2
Entrez Gene ID: (Rat) 362675, (Mouse) 22062
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
p53 binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein kinase binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein binding
metal ion binding
P53-like transcription factor
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
kidney development
release of cytochrome c from mitochondria
transcription from RNA polymerase II promoter
inflammatory response
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle arrest
regulation of mitotic cell cycle
post-embryonic development
response to X-ray
response to organonitrogen compound
response to gamma radiation
regulation of gene expression
hippocampus development
forebrain development
mitotic G1 DNA damage checkpoint
cerebrospinal fluid secretion
cellular response to UV
response to drug
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic process
negative regulation of JUN kinase activity
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of cell size
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract morphogenesis
neuron development
positive regulation of oligodendrocyte differentiation
protein tetramerization
negative regulation of cardiac muscle cell proliferation
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of apoptotic signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
cell cycle
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